Recent highlights

Origin of entorhinal cortex grid field spacing. In entorhinal cortex, stellate cell oscillation frequency correlates with grid field size. Modeling shows that variation in HCN-channel characteristics may underlie the gradient in stellate cell oscillation frequency and that cells with these properties may result in grid field-like firing patterns when included in a virtual rat.
(Giocomo et al, Science, 2007)

Origin of intrinsic graded firing levels. Modeling shows that graded levels in entorhinal cortex may depend on two separate pathways whose activation is separated by a neutral region. Further, graded levels do not depend on intracellular calcium stores, and they do not appear to be discretely spaced. 
(FransÚn et al, Neuron, 2006)


Pyramidal cells in entorhinal cortex show intrinsic graded levels of firing. These levels can also be upgraded or downgraded by synaptic stimulation. Graded levels depend on intracellular calcium and of a mixed cation channel (TRP-type) activated by muscarinic receptors. 
(Egorov et al, Nature, 2002)

Working memory function depending on medial temporal lobe structures may depend on activation of a mixed cationic ion channel in entorhinal cortex pyramidal neurons. A simulated small network shows the functional cell classes found in behavioural experiments, like delay cells or match enhancement cells. 
(FransÚn et al, J. Neurosci, 2002)